Last edited by Telkree
Monday, August 10, 2020 | History

7 edition of Mass spectrometry in drug discovery found in the catalog.

Mass spectrometry in drug discovery

  • 309 Want to read
  • 34 Currently reading

Published by Marcel Dekker in New York .
Written in English

    Subjects:
  • Drugs -- Analysis.,
  • Mass spectrometry.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by David T. Rossi and Michael W. Sinz.
    ContributionsRossi, David T., Sinz, Michael W.
    Classifications
    LC ClassificationsRS189.5.S65 M37 2002
    The Physical Object
    Paginationviii, 420 p. :
    Number of Pages420
    ID Numbers
    Open LibraryOL3657817M
    ISBN 100824706072
    LC Control Number2002512691
    OCLC/WorldCa48959276

    Mass Spectrometry for Drug Discovery and Drug Development - Ebook written by Walter A. Korfmacher. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Mass Spectrometry for Drug Discovery and Drug Development. Drug Discovery & Disease Evaluations Strategies for Quantitative Proteomics presented by M. Arthur Moseley (Duke University) on June 3, Cancer Immunotherapy and Mass Spectrometry presented by Donald F. Hunt (University of Virginia) on June 4,

    Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative. Title: Mass Spectrometry in Drug Discovery: A Current Review VOLUME: 1 ISSUE: 4 Author(s):Wan Yong Feng Affiliation:PK/DM Department, Mail Stop , Chiron Corporation, Horton Street, Emeryville, CA , USA. Keywords:mass spectrometry, liquid chromatography, quantitation, qualitation, drugs, metabolites, adme/pk Abstract: Drug discovery in the pharmaceutical industry has .

    A Brief History of Mass Spectrometry. – Modern mass spectrometry (MS) is credited to the cathode-ray-tube experiments of J.J. Thomson of Manchester, England. – Wolfgang Paul’s invention of the quadrupole and quadrupole ion trap earned him the Nobel Prize in physics. Mass Spectrometry in Drug Discovery edited by David T. Rossi and Michael W. Sinz • pages • $ + shipping. Texas residents please add 7 % sales tax.


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Mass spectrometry in drug discovery Download PDF EPUB FB2

Facilitates the discovery and development of new, effective therapeutics. With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug.

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery. An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last Brand: Wiley.

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (Methods and Principles in Medicinal Chemistry): Medicine & Health Science Books Price: $ Book Description.

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates.

Mass Spectrometry in Drug Discovery book. Mass Spectrometry in Drug Discovery. DOI link for Mass Spectrometry in Drug Discovery. Mass Spectrometry in Drug Discovery book. Edited By David T. Rossi, Michael Sinz. Edition 1st Edition. First Published eBook Published 7 November Cited by: ALIS: An Affinity Selection–Mass Spectrometry System for the Discovery and Characterization of Protein–Ligand Interactions (Pages: ) Allen Annis Cheng‐Chi Chuang.

Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery.

Mass spectrometry (MS) is a powerful analytical tool with many applications in pharmaceutical and biomedical field. The increase in sensitivity and resolution of the instrument has opened new dimensions in analysis of pharmaceuticals and complex metabolites of biological systems.

Compared with other techniques, mass spectroscopy is only the technique for molecular weight. "It is a state-of-the-art and mostly comprehensive overview of the field. It will be a valuable source of information for all those who want to start in the fields of drug metabolism and MS, e.g., PhD students, but also senior scientists, etc." (Analytical and Bioanalytical Chemistry, 31 July )"Overall, Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting.

THIS BOOK: * Clearly explains how drug discovery and mass spectrometry are interconnected * Discusses the uses and limitations of various types of mass spectrometry in various aspects of drug discovery * Prominently features analytical applications that require trace-mixture analysis * Provides industry applications and real-world examplesCited by:   Due to space constraints, we focus in this review on the contributions of mass spectrometry-based proteomics to the preclinical stages of small molecule drug discovery.

For clinical applications of proteomics including biomarker discovery, we refer the interested reader to a number of reviews that have been published on the topic (Rifai et al. Mass Spectrometry in Drug Discovery David T. Rossi, Michael Sinz Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates.

Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field.

The book stresses practice and applications, providing real world examples from industry contributors. The book starts with an overview of protein mass spectrometry (MS) methodology, followed by a discussion of studies involving the characterization of proteins and special topics related to drug discovery.

Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry Jun Zhang, Ramona Rodila, Huaiqin Wu, Tawakol A.

El-Shourbagy Pages Publisher Summary. Mass spectrometry is making new inroads into the biomedical applications area. With the availability of dedicated instrumentation and the expanding discovery of disease biomarkers, diagnostic laboratories would increasingly turn to mass spectrometric methods.

Mass Spectrometry in Drug Discovery; find Sigma-M MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. ISBN: OCLC Number: Description: viii, pages: illustrations ; 26 cm: Contents: Demand for drug discovery today / Michael W.

Sinz --Impact of atmospheric pressure ionization / David T. Rossi --Mass spectrometry primer / Scott T. Fountain --Ion chemistry and fragmentation / Richard A.J. O'Hair --LC/MS experiment / Lucinda R.H. Cohen and David T. Rossi. Mass spectrometry and drug efficacy In biopharma mass spectrometry play a role in measuring drug efficacy often by analyzing downstream effects.

“We can employ it for looking at the biological consequence of the drug-target binding,” says Stawicki, “for example, we can use mass spectrometry to look at phosphorylation of a messenger.

"Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting resource for a broad readership, including scientists starting to work in DMPK as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of MS.

A wealth of information is provided and all of the Author: Ragu Ramanathan. Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications.

The books fifteen chapters have been written by leading pharmaceutical and analytical scientists."Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting resource for a broad readership, including scientists starting to work in DMPK as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of MS.

A wealth of information is provided and all of the. Over the last decade mass spectrometry imaging (MSI) has been integrated in to many areas of drug discovery and development. It can have significant impact in oncology drug discovery as it allows efficacy and safety of compounds to be assessed against the backdrop of the complex tumour microenvironment.